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Since the earliest days of the industrial revolution, industrial processes working under other than atmospheric pressures, have typically required (mandatory) measures to assure a safe operation. As a first line of defense, pressure control systems such as relief valves and rupture (bursting) discs are primarily used, each offering specific features and providing the system designer viable solution choices. The following paper explores the strengths of relief valves, rupture discs and the use of a combination of both – from environmental and cost differentials to safety/reliability levels and performance factors.